Pharmacological Topics of Bone Metabolism: Preface
نویسندگان
چکیده
منابع مشابه
Pharmacological topics of bone metabolism. Preface.
This Forum Minireview contains the proceedings of the symposium at the 80th Annual meeting of The Japanese Pharmacological Society (March 27, 2007). With the growing incidence of fragility fractures, bone loss and osteoporosis have become active areas of research in clinical and experimental pharmacology. The symposium aimed to summarize recent advances and trends in elucidating the pathophysio...
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The prevention of osteoporotic fracture is an essential socioeconomical priority, especially in the developed countries including Japan. Estrogen, selective estrogen-receptor modulators (SERMs), and bisphosphonate are potent inhibitors of bone resorption; and they have clinical relevance to reduce osteoporotic fractures in postmenopausal women. However, we can prevent at most 50% of vertebral f...
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Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2008
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.fm0070233